TORC1 specifically inhibits microautophagy through ESCRT-0
نویسندگان
چکیده
منابع مشابه
Evidence for ESCRT- and clathrin-dependent microautophagy
Microautophagy refers to a mode of autophagy in which the lysosomal or vacuolar membrane invaginates and directly engulfs target components. The molecular machinery of membrane dynamics driving microautophagy is still elusive. Using immunochemical monitoring of yeast vacuolar transmembrane proteins, Vph1 and Pho8, fused to fluorescent proteins, we obtained evidence showing an induction of micro...
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The human Hrs and STAM proteins comprise the ESCRT-0 complex, which sorts ubiquitinated cell surface receptors to lysosomes for degradation. Here we report a model for the complete ESCRT-0 complex based on the crystal structure of the Hrs-STAM core complex, previously solved domain structures, hydrodynamic measurements, and Monte Carlo simulations. ESCRT-0 expressed in insect cells has a hydrod...
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ژورنال
عنوان ژورنال: Current Genetics
سال: 2019
ISSN: 0172-8083,1432-0983
DOI: 10.1007/s00294-019-00982-y